Gene information
Official symbol ADRA2B
Official full name adrenoceptor alpha 2B
Gene type protein-coding gene
Chromosome2q11.2
Alias symbolADRARL1
Previous symbolADRA2L1; ADRA2RL1
Gene familyAdrenoceptors
Resources
Entrez Gene 151
HGNC HGNC:282
Ensembl ENSG00000274286
Vega OTTHUMG00000188276
UCSC uc032nvj.2
GO terms: 45 records
GO Description Category LogP Number of genes Detail
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0004935 adrenergic receptor activity GO Molecular Functions -7.55914528 5 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006940 regulation of smooth muscle contraction GO Biological Processes -12.9613663 21 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Processes -6.95524830 22 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0008227 G protein-coupled amine receptor activity GO Molecular Functions -5.63918224 7 More
GO:0010469 regulation of signaling receptor activity GO Biological Processes -13.5880476 20 More
GO:0010700 negative regulation of norepinephrine secretion GO Biological Processes -4.82387082 4 More
GO:0014061 regulation of norepinephrine secretion GO Biological Processes -4.75202065 4 More
GO:0019229 regulation of vasoconstriction GO Biological Processes -25.9471687 22 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0032148 activation of protein kinase B activity GO Biological Processes -8.71311579 12 More
GO:0033604 negative regulation of catecholamine secretion GO Biological Processes -3.89921208 5 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045933 positive regulation of muscle contraction GO Biological Processes -10.2635447 16 More
GO:0045987 positive regulation of smooth muscle contraction GO Biological Processes -5.46031079 9 More
GO:0050433 regulation of catecholamine secretion GO Biological Processes -6.37680507 13 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051379 epinephrine binding GO Molecular Functions -4.49239295 3 More
GO:0051952 regulation of amine transport GO Biological Processes -10.5179624 22 More
GO:0051953 negative regulation of amine transport GO Biological Processes -4.82877039 5 More
GO:0071875 adrenergic receptor signaling pathway GO Biological Processes -8.98205881 11 More
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO Biological Processes -9.78130162 11 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:1901338 catecholamine binding GO Molecular Functions -6.56692149 5 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:2000273 positive regulation of signaling receptor activity GO Biological Processes -8.61037442 14 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
Drug-Gene interaction
view
Related drugs: 49 records
Drug name Interaction type Source PMID View
alseroxylon antagonist ChemblInteractions view
apraclonidine hydrochloride agonist ChemblInteractions view
asenapine antagonist TdgClinicalTrial 18308814 view
bethanidine TdgClinicalTrialTEND view
brimonidine agonist TENDPharmGKB 146106378097565 view
brimonidine tartrate agonist ChemblInteractions view
clonidine agonist TdgClinicalTrialChemblInteractionsPharmGKB 11082457 view
clonidine hydrochloride agonist ChemblInteractions view
debrisoquin TdgClinicalTrialTEND view
dexmedetomidine hydrochloride agonist ChemblInteractions view
dipivefrin hydrochloride agonist ChemblInteractions view
dopamine PharmGKB view
droxidopa agonist ChemblInteractions 211738501806441718680204 view
epinephrine agonist TdgClinicalTrialChemblInteractionsPharmGKB 613452911053214180644171979424198023611728431 view
epinephrine bitartrate agonist ChemblInteractions view
ergoloid mesylates antagonist ChemblInteractions view
esmirtazapine maleate antagonist ChemblInteractions view
etomidate agonist TdgClinicalTrialTEND 2049652214508322 view
fadolmidine hydrochloride agonist ChemblInteractions view
fenoldopam antagonist TEND 76707371713928417016423 view
fipamezole TdgClinicalTrial view
guanabenz acetate agonist ChemblInteractions view
guanfacine hydrochloride agonist ChemblInteractions view
hydroxyamphetamine hydrobromide agonist ChemblInteractions view
isoproterenol PharmGKB view
labetalol hydrochloride antagonist ChemblInteractions view
levonordefrin agonist ChemblInteractions view
lofexidine agonist TdgClinicalTrialTEND view
medetomidine TTD view
mephentermine sulfate agonist ChemblInteractions view
methamphetamine agonist TdgClinicalTrial 955176915955613 view
methyldopa agonist ChemblInteractions view
methyldopate hydrochloride agonist ChemblInteractions view
mirtazapine antagonist ChemblInteractions view
moxonidine TTD view
naphazoline hydrochloride agonist ChemblInteractions view
norepinephrine agonist TdgClinicalTrialTENDPharmGKB 110532141806441719794241980236171392841701642311728431 view
norepinephrine bitartrate agonist ChemblInteractions view
olanzapine antagonist TdgClinicalTrial 17848919 view
oxymetazoline hydrochloride agonist ChemblInteractions view
phenoxybenzamine hydrochloride antagonist ChemblInteractions view
phentolamine mesylate antagonist ChemblInteractions view
rauwolfia serpentina antagonist ChemblInteractions view
senrebotase TdgClinicalTrial view
tetrahydrozoline hydrochloride agonist ChemblInteractions view
tizanidine agonist TdgClinicalTrial 8930173 view
tizanidine hydrochloride agonist ChemblInteractions view
tolazoline hydrochloride antagonist ChemblInteractions view
yohimbine antagonist TdgClinicalTrialTENDPharmGKB 88723611712371712110610121700551082206610611634 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
NM_000682.7:c.893_900dup genomics acute myocardial infarction[diagnosis] acute myocardial infarction Snapir A et al. J Am Coll Cardiol. 2003
NM_000682.7:c.893_900dup genomics myocardial infarction[diagnosis] myocardial infarction Xia K et al. Gene. 2017
All rights reserved: Soochow University Center for Systems Biology